Across TCGA pan-cancer cohorts, ACKR1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ACKR1 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ACKR1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACKR1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

LUAD, HNSC, and LSCC are the cancer types where ACKR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.202	0.790	<.001	18	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.883	.035	10	view →
LSCC	OS	Median	II,III,IV	0.942	0.649	.013	7	view →
PDAC	DFS	Median	All	0.568	0.233	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ACKR1 tumor-vs-normal RNA expression · all ACKR1 data types