Across TCGA patient cohorts, ACKR1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,155 significant associations in total. OV shows the largest number of these associations.

The most reproducible ACKR1-associated genes across cancer lineages are HBA2, HBA1, and HBB. Each is linked with ACKR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ACKR1-to-partner and partner-to-ACKR1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACKR1→partner) and Y-score (partner→ACKR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HBA2 →	+2.130	+0.627	.002	<.001	3	4
CCRCC	HBA1 →	+1.981	+0.584	<.001	<.001	3	4
CCRCC	HBB →	+2.497	+0.560	<.001	<.001	3	4
PDAC	RAB3C →	+1.307	+1.012	.003	.008	3	3
OV	TMEM88 →	+0.934	+1.177	<.001	<.001	3	3
CCRCC	HEMGN →	+0.893	+0.431	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,155 associations by consensus.

Exploration

ACKR1 survival (RNA) · tumor vs normal (RNA) · all ACKR1 data types