Across TCGA patient cohorts, ACKR1 mutation is significantly associated with the RNA expression of many other genes, with 2,378 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACKR1-associated genes across cancer lineages are SEC61A2, CETP, and C19orf54. Each is linked with ACKR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACKR1-to-partner and partner-to-ACKR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACKR1→partner) and Y-score (partner→ACKR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC61A2 →	+0.467	+3.647	.002	.001	3	3
UCEC	CETP →	-0.527	-3.758	<.001	<.001	3	3
UCEC	C19orf54 →	+0.388	+2.180	.001	.002	3	3
UCEC	LONP1 →	+0.736	+2.673	<.001	<.001	3	3
COAD	NDUFA5P5 →	+0.144	+5.332	<.001	.002	3	3
UCEC	RNY1P1 →	+0.179	+3.165	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,378 associations by consensus.

Exploration

ACKR1 survival (RNA) · tumor vs normal (RNA) · all ACKR1 data types