Across TCGA patient cohorts, ACKR1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACKR1-associated genes across cancer lineages are MYH11, PDCD4, and Stathmin. Each is linked with ACKR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACKR1-to-partner and partner-to-ACKR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACKR1→partner) and Y-score (partner→ACKR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MYH11 →	-1.051	-3.000	.017	.035	3	2
UCEC	PDCD4 →	-0.618	-3.169	.001	.018	3	2
LUAD	Stathmin →	+0.240	+2.841	.004	.033	3	2
LUAD	XRCC1 →	+0.286	+3.195	<.001	.009	3	2
UCEC	AR →	-0.384	-1.807	.012	.027	3	2
UCEC	EGFR_pY1068 →	-0.272	-3.169	.008	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

ACKR1 survival (RNA) · tumor vs normal (RNA) · all ACKR1 data types