ACHE

Across TCGA patient cohorts, ACHE mutation is significantly associated with the RNA expression of many other genes, with 2,404 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACHE-associated genes across cancer lineages are TXN2, RFC5, and ACYP1. Each is linked with ACHE in more than 2 cancer types. Because this analysis shows association rather than direction, both ACHE-to-partner and partner-to-ACHE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXN2 grouped by ACHE-low versus ACHE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACHE→partner) and Y-score (partner→ACHE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TXN2 →	+0.316	+2.617	.002	.005	3	3
UCEC	RFC5 →	+0.407	+1.914	.009	.009	3	3
UCEC	ACYP1 →	+0.385	+1.684	.007	.007	3	3
UCEC	SLC66A2 →	+0.394	+3.828	.004	<.001	3	3
UCEC	ZWINT →	+0.757	+3.906	<.001	<.001	3	3
UCEC	GCH1 →	+0.774	+2.424	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,404 associations by consensus.

TXN2 by ACHE expression — UCEC

Explore this box plot interactively →