ACHE

Across TCGA patient cohorts, ACHE mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACHE-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and MEK1. Each is linked with ACHE in more than 2 cancer types. Because this analysis shows association rather than direction, both ACHE-to-partner and partner-to-ACHE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ACHE-low versus ACHE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACHE→partner) and Y-score (partner→ACHE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.404	-2.087	.020	.005	3	3
UCEC	Caspase-7-cleavedD198 →	+0.869	+2.926	<.001	<.001	3	3
UCEC	MEK1 →	+0.296	+1.678	.035	.023	3	2
UCEC	mTOR_pS2448 →	-0.153	-3.446	.007	.005	3	2
UCEC	PCNA →	+0.199	+2.087	.016	.005	3	2
UCEC	14-3-3_beta →	-0.081	-1.847	.036	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ATM by ACHE expression — UCEC

Explore this box plot interactively →