ACHE

Across TCGA cell cohorts, ACHE RNA expression is significantly associated with the go_rna of many other GO terms, with 3,112 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACHE-associated GO terms across cancer lineages are Negative regulation of protein deubiquitination, Mitochondrial electron transport, cytochrome c to oxygen, and Positive regulation of TORC1 signaling. Each is linked with ACHE in more than 8 cancer types. Because this analysis shows association rather than direction, both ACHE-to-partner and partner-to-ACHE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein deubiquitination grouped by ACHE-low versus ACHE-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACHE→partner) and Y-score (partner→ACHE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Negative regulation of protein deubiquitination →	+0.105	+1.026	<.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	Mitochondrial electron transport, cytochrome c to oxygen →	+0.127	+0.912	<.001	.001	3	9
KIDNEY	Positive regulation of TORC1 signaling →	+0.074	+1.715	.001	.001	3	8
OVARY	Proton transmembrane transport →	+0.092	+1.094	<.001	.002	3	8
UPPER_AERODIGESTIVE_TRACT	Spermatid differentiation →	-0.030	-0.704	.003	.008	3	8
BLOOD_Lymphoma	Protein targeting to vacuole involved in autophagy →	+0.137	+1.088	.002	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,112 associations by consensus.

Negative regulation of protein deubiquitination by ACHE expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →