ACHE

Across TCGA cell cohorts, ACHE mutation is significantly associated with the RNA expression of many other genes, with 298 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACHE-associated genes across cancer lineages are KRTAP8-1, IL2, and WFDC11. Each is linked with ACHE in more than 1 cancer types. Because this analysis shows association rather than direction, both ACHE-to-partner and partner-to-ACHE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP8-1 grouped by ACHE-low versus ACHE-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACHE→partner) and Y-score (partner→ACHE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KRTAP8-1 →	+0.073	+5.643	<.001	.002	3	1
BLOOD_Leukemia	IL2 →	+0.989	+4.276	<.001	.007	3	1
BLOOD_Leukemia	WFDC11 →	+0.030	+4.539	<.001	.007	3	1
BLOOD_Leukemia	CNGA2 →	+0.074	+4.539	<.001	.007	3	1
BLOOD_Leukemia	CDR1 →	+0.070	+5.060	<.001	.001	3	1
BLOOD_Leukemia	GALP →	+0.059	+5.786	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 298 associations by consensus.

KRTAP8-1 by ACHE expression — LUNG_SCLC

Explore this box plot interactively →