ACHE

Across TCGA cell cohorts, ACHE mutation is significantly associated with the mutation status of many other genes, with 3,415 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACHE-associated genes across cancer lineages are MTA2, AP3D1, and KCTD8. Each is linked with ACHE in more than 3 cancer types. Because this analysis shows association rather than direction, both ACHE-to-partner and partner-to-ACHE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTA2 grouped by ACHE-low versus ACHE-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACHE→partner) and Y-score (partner→ACHE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MTA2 →	+5.000	+4.187	.008	.008	1	4
BLOOD_Leukemia	AP3D1 →	+3.753	+5.347	<.001	<.001	1	4
LARGE_INTESTINE	KCTD8 →	+2.471	+2.369	.005	.005	1	4
LUNG_NSCLC_LUAD	LAMA1 →	+2.299	+3.999	.005	.005	1	3
LUNG_NSCLC_LUAD	CD93 →	+4.000	+4.303	.001	.001	1	3
LUNG_NSCLC_LUAD	SLC27A1 →	+5.000	+4.187	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,415 associations by consensus.

MTA2 by ACHE expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →