ACER2P1

Across TCGA pan-cancer cohorts, ACER2P1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ACER2P1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ACER2P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ACER2P1 is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.

HNSC, LUSC, and ESCA are the cancer types where ACER2P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACER2P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.036	<.001	9	view →
LUSC	All	All	+0.025	.007	5	view →
ESCA	All	II,III,IV	−0.084	.016	2	view →
LIHC	All	All	+0.018	.010	2	view →
KIRC	Male	All	+0.021	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ACER2P1–HNSC

Open the HNSC breakdown →