ACER2

Across TCGA patient cohorts, ACER2 mutation is significantly associated with the RNA expression of many other genes, with 887 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACER2-associated genes across cancer lineages are RPS29P31, RNA5SP358, and RNA5SP251. Each is linked with ACER2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACER2-to-partner and partner-to-ACER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P31 grouped by ACER2-low versus ACER2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACER2→partner) and Y-score (partner→ACER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPS29P31 →	+0.382	+5.357	<.001	.006	3	2
UCEC	RNA5SP358 →	+0.350	+2.798	<.001	.001	3	2
UCEC	RNA5SP251 →	+0.616	+2.966	<.001	.002	3	2
UCEC	ZNHIT3 →	+0.483	+3.928	.003	<.001	3	1
UCEC	UHRF1 →	+0.989	+3.584	<.001	.002	3	1
SKCM	GOLGA6L22 →	+0.011	+5.508	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 887 associations by consensus.

RPS29P31 by ACER2 expression — COAD

Explore this box plot interactively →