ACER2

Across TCGA patient cohorts, ACER2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACER2-associated genes across cancer lineages are GAPDH, A-Raf_pS299, and JNK2. Each is linked with ACER2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACER2-to-partner and partner-to-ACER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ACER2-low versus ACER2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACER2→partner) and Y-score (partner→ACER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.723	+2.999	.003	.035	3	2
UCEC	A-Raf_pS299 →	-0.111	-3.000	.047	.036	3	1
UCEC	JNK2 →	+0.279	+2.834	.002	.034	3	1
UCEC	MEK1 →	+0.510	+3.459	.002	.005	3	1
UCEC	Mre11 →	-0.088	-2.973	.027	.035	3	1
UCEC	AR →	-0.503	-3.700	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GAPDH by ACER2 expression — UCEC

Explore this box plot interactively →