ACER1

Across TCGA patient cohorts, ACER1 mutation is significantly associated with the RNA expression of many other genes, with 1,565 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACER1-associated genes across cancer lineages are RN7SL837P, RN7SL97P, and CTBP2P10. Each is linked with ACER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACER1-to-partner and partner-to-ACER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL837P grouped by ACER1-low versus ACER1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACER1→partner) and Y-score (partner→ACER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL837P →	+0.069	+3.993	<.001	.008	3	2
SKCM	RN7SL97P →	+0.074	+3.645	<.001	.003	3	2
SKCM	CTBP2P10 →	+0.013	+3.993	<.001	.008	3	2
UCEC	CENPU →	+0.847	+2.743	<.001	.002	3	2
UCEC	GPATCH11 →	+0.452	+2.233	.004	.006	3	2
UCEC	HELQ →	+0.369	+3.483	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,565 associations by consensus.

RN7SL837P by ACER1 expression — SKCM

Explore this box plot interactively →