ACER1

Across TCGA patient cohorts, ACER1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACER1-associated genes across cancer lineages are GAPDH, TFRC, and ACC_pS79. Each is linked with ACER1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACER1-to-partner and partner-to-ACER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ACER1-low versus ACER1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACER1→partner) and Y-score (partner→ACER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.694	+3.169	.005	.019	2	3
UCEC	TFRC →	+0.603	+3.700	.014	.001	3	2
UCEC	ACC_pS79 →	+0.421	+2.584	.009	.011	3	1
UCEC	N-Ras →	-0.142	-2.571	.010	.011	3	1
UCEC	Akt_pS473 →	+0.754	+2.321	.023	.034	3	1
UCEC	PI3K-p110-a →	-0.166	-2.584	.043	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

GAPDH by ACER1 expression — UCEC

Explore this box plot interactively →