ACER1

Across TCGA cell cohorts, ACER1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,966 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACER1-associated GO terms across cancer lineages are Response to alkaline pH, Ureteric bud formation, and Regulation of postsynaptic density protein 95 clustering. Each is linked with ACER1 in more than 6 cancer types. Because this analysis shows association rather than direction, both ACER1-to-partner and partner-to-ACER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to alkaline pH grouped by ACER1-low versus ACER1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACER1→partner) and Y-score (partner→ACER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Response to alkaline pH →	+0.232	+0.627	<.001	<.001	3	7
BLOOD_Leukemia	Ureteric bud formation →	+0.996	+0.142	<.001	<.001	3	5
KIDNEY	Regulation of postsynaptic density protein 95 clustering →	-0.066	-0.016	.001	.004	3	5
LUNG_NSCLC_LUSC	Positive regulation of macrophage derived foam cell differentiation →	-0.217	-0.038	.001	.005	3	5
LUNG_NSCLC_LUSC	Autophagy of mitochondrion →	+0.050	+0.037	.009	.008	3	5
BLOOD_Leukemia	Regulation of G1/S transition of mitotic cell cycle →	+0.047	+0.190	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,966 associations by consensus.

Response to alkaline pH by ACER1 expression — BREAST

Explore this box plot interactively →