ACE2

Across TCGA patient cohorts, ACE2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACE2-associated genes across cancer lineages are MEK1, Shc_pY317, and EGFR_pY1068. Each is linked with ACE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACE2-to-partner and partner-to-ACE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ACE2-low versus ACE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACE2→partner) and Y-score (partner→ACE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.364	+1.925	.002	.004	3	2
UCEC	Shc_pY317 →	-0.143	-1.765	.003	.013	3	2
UCEC	EGFR_pY1068 →	-0.252	-2.000	.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.097	-1.222	.012	.035	3	1
UCEC	ERK2 →	+0.155	+1.502	.013	.027	3	1
UCEC	INPP4B →	-0.273	-2.321	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MEK1 by ACE2 expression — UCEC

Explore this box plot interactively →