ACE2

Across TCGA cell cohorts, ACE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,242 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ACE2-associated GO terms across cancer lineages are Regulation of protein localization to membrane, Digestive system process, and Bundle of His cell to Purkinje myocyte communication. Each is linked with ACE2 in more than 7 cancer types. Because this analysis shows association rather than direction, both ACE2-to-partner and partner-to-ACE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to membrane grouped by ACE2-low versus ACE2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACE2→partner) and Y-score (partner→ACE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of protein localization to membrane →	+0.067	+0.871	<.001	.003	3	8
LARGE_INTESTINE	Digestive system process →	+0.168	+1.933	<.001	<.001	3	8
BREAST	Bundle of His cell to Purkinje myocyte communication →	+0.349	+1.198	.004	.002	3	8
STOMACH	Action potential propagation →	-1.087	-1.598	<.001	<.001	3	8
URINARY_TRACT	Lipoxin biosynthetic process →	+1.613	+1.718	<.001	.003	3	7
URINARY_TRACT	Positive regulation of sodium ion transport →	+0.221	+2.120	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,242 associations by consensus.

Regulation of protein localization to membrane by ACE2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →