ACE

Across TCGA pan-cancer cohorts, ACE mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ACE data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ACE mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACE expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

COAD, HNSC, and LSCC are the cancer types where ACE mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.793	1.000	.027	24	view →
HNSC	DFS	Quartile	All	0.652	0.898	.011	9	view →
LSCC	OS	Quartile	III,IV	0.980	0.754	.045	4	view →
PDAC	OS	Tertile	IV	0.252	0.956	.024	4	view →
GBM	DFS	Tertile	All	0.807	0.627	.026	2	view →
CCRCC	OS	Tertile	III,IV	0.870	0.550	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ACE–COAD (DFS)

Open the COAD breakdown →