ACE

Across TCGA patient cohorts, ACE RNA expression is significantly associated with the protein abundance of many other proteins, with 9,915 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ACE-associated proteins across cancer lineages are CTSZ, PECAM1, and ZEB2. Each is linked with ACE in more than 4 cancer types. Because this analysis shows association rather than direction, both ACE-to-partner and partner-to-ACE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACE versus CTSZ in GBM, with a Pearson correlation of 0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ACE→partner) and Y-score (partner→ACE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CTSZ →	+0.399	+0.533	.005	.001	3	5
OV	PECAM1 →	+0.417	+0.439	.001	.007	3	5
LSCC	ZEB2 →	+0.352	+0.713	<.001	<.001	3	4
LSCC	STK10 →	+0.434	+0.634	<.001	<.001	3	4
LSCC	CARD9_S460 →	+0.544	+0.571	.001	.001	3	4
GBM	CD93 →	+0.451	+0.637	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,915 associations by consensus.

ACE vs CTSZ — GBM

Explore this scatter interactively →