ACE

Across TCGA patient cohorts, ACE protein abundance is significantly associated with the RNA expression of many other genes, with 9,704 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ACE-associated genes across cancer lineages are VSIG4, ACP5, and LILRB5. Each is linked with ACE in more than 6 cancer types. Because this analysis shows association rather than direction, both ACE-to-partner and partner-to-ACE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACE versus VSIG4 in COAD, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACE→partner) and Y-score (partner→ACE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	VSIG4 →	+0.997	+0.429	<.001	<.001	3	7
GBM	ACP5 →	+1.164	+0.375	<.001	.001	3	6
GBM	LILRB5 →	+0.877	+0.426	<.001	<.001	3	6
GBM	CD93 →	+0.873	+0.452	<.001	<.001	3	6
HNSC	CLEC10A →	+1.051	+0.258	<.001	<.001	3	6
PDAC	TMEM150B →	+0.839	+0.365	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,704 associations by consensus.

ACE vs VSIG4 — COAD

Explore this scatter interactively →