ACE

Across TCGA cell cohorts, ACE RNA expression is significantly associated with the RNA expression of many other genes, with 5,529 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACE-associated genes across cancer lineages are LRRC43, DOK1, and PPM1M. Each is linked with ACE in more than 5 cancer types. Because this analysis shows association rather than direction, both ACE-to-partner and partner-to-ACE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACE versus LRRC43 in LUNG_SCLC, with a Pearson correlation of 0.46.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACE→partner) and Y-score (partner→ACE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LRRC43 →	+1.450	+1.729	<.001	.001	3	5
OESOPHAGUS	DOK1 →	+1.685	+1.665	<.001	.004	2	6
SKIN	PPM1M →	+1.127	+0.372	<.001	.004	2	5
LUNG_SCLC	TTLL6 →	+1.018	+1.629	.001	.001	2	5
UPPER_AERODIGESTIVE_TRACT	IFT140 →	+1.139	+0.570	<.001	.001	2	5
OVARY	CLDN3 →	+3.346	+1.038	.001	.009	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,529 associations by consensus.

ACE vs LRRC43 — LUNG_SCLC

Explore this scatter interactively →