ACE

Across TCGA cell cohorts, ACE RNA expression is significantly associated with the go_rna of many other GO terms, with 2,480 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ACE-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Regulation of myoblast fusion. Each is linked with ACE in more than 10 cancer types. Because this analysis shows association rather than direction, both ACE-to-partner and partner-to-ACE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by ACE-low versus ACE-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACE→partner) and Y-score (partner→ACE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of myoblast fusion →	+0.120	+2.082	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.134	+0.789	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.121	+0.708	<.001	.009	3	10
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.119	+2.122	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Cytoplasmic translation →	+0.099	+0.909	<.001	<.001	3	8
SOFT_TISSUE	Positive regulation of inflammatory response to wounding →	+0.263	+0.594	<.001	.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,480 associations by consensus.

Negative regulation of myoblast fusion by ACE expression — LUNG_SCLC

Explore this box plot interactively →