ACE

Across TCGA cell cohorts, ACE mutation is significantly associated with the RNA expression of many other genes, with 949 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACE-associated genes across cancer lineages are PPP4R3A, ADNP2, and SEMA3G. Each is linked with ACE in more than 1 cancer types. Because this analysis shows association rather than direction, both ACE-to-partner and partner-to-ACE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP4R3A grouped by ACE-low versus ACE-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACE→partner) and Y-score (partner→ACE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP4R3A →	+0.447	+2.714	.002	.002	3	2
LARGE_INTESTINE	ADNP2 →	+0.874	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	SEMA3G →	+0.812	+2.628	<.001	.002	3	2
LARGE_INTESTINE	MREG →	+0.592	+2.714	<.001	.002	3	2
LARGE_INTESTINE	SLC25A51 →	+0.574	+3.169	.001	.006	3	2
LARGE_INTESTINE	SPCS3 →	+0.533	+3.743	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 949 associations by consensus.

PPP4R3A by ACE expression — LARGE_INTESTINE

Explore this box plot interactively →