ACD

Across TCGA pan-cancer cohorts, ACD mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ACD data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ACD mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ACD expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

UCEC, HNSC, and LSCC are the cancer types where ACD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.638	1.000	.014	40	view →
HNSC	DFS	Median	IV	0.366	0.844	.021	13	view →
LSCC	OS	Tertile	All	0.879	0.611	.007	3	view →
PDAC	OS	Median	II,III,IV	1.000	0.831	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ACD–UCEC (OS)

Open the UCEC breakdown →