ACD

Across TCGA patient cohorts, ACD protein abundance is significantly associated with the RNA expression of many other genes, with 3,859 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ACD-associated genes across cancer lineages are NME2P2, FGF1, and RIT1. Each is linked with ACD in more than 1 cancer types. Because this analysis shows association rather than direction, both ACD-to-partner and partner-to-ACD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACD versus NME2P2 in GBM, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACD→partner) and Y-score (partner→ACD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NME2P2 →	+0.382	+0.300	.004	<.001	3	2
GBM	FGF1 →	-0.921	-0.288	.003	.005	3	2
LUAD	RIT1 →	-0.461	-0.237	.001	.002	3	2
GBM	DIPK2B →	-0.571	-0.340	.001	.002	3	2
BRCA	HAUS1 →	+0.722	+0.221	<.001	.006	3	2
BRCA	PRND →	-0.627	-0.191	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,859 associations by consensus.

ACD vs NME2P2 — GBM

Explore this scatter interactively →