ACD

Across TCGA cell cohorts, ACD mutation is significantly associated with the RNA expression of many other genes, with 243 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACD-associated genes across cancer lineages are GPR101, GZMK, and C20orf173. Each is linked with ACD in more than 1 cancer types. Because this analysis shows association rather than direction, both ACD-to-partner and partner-to-ACD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR101 grouped by ACD-low versus ACD-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACD→partner) and Y-score (partner→ACD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPR101 →	+0.070	+4.906	<.001	.006	3	1
BLOOD_Leukemia	GZMK →	+0.412	+4.037	.008	.004	3	1
BLOOD_Leukemia	C20orf173 →	+0.105	+4.133	<.001	.003	3	1
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1
BLOOD_Leukemia	BTBD16 →	+0.107	+3.959	<.001	.005	3	1
BLOOD_Leukemia	DCLK3 →	+0.271	+3.769	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 243 associations by consensus.

GPR101 by ACD expression — OESOPHAGUS

Explore this box plot interactively →