ACCS

Across TCGA patient cohorts, ACCS mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACCS-associated genes across cancer lineages are Caspase-7-cleavedD198, p62 Lck ligand, and PCNA. Each is linked with ACCS in more than 3 cancer types. Because this analysis shows association rather than direction, both ACCS-to-partner and partner-to-ACCS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ACCS-low versus ACCS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACCS→partner) and Y-score (partner→ACCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.587	+1.434	.002	.027	3	4
UCEC	p62 Lck ligand →	+0.479	+4.807	<.001	<.001	3	2
UCEC	PCNA →	+0.238	+1.736	<.001	.006	3	2
UCEC	ATM →	-0.561	-2.263	<.001	<.001	3	2
UCEC	c-Kit →	-0.177	-1.392	.021	.019	3	2
UCEC	eEF2 →	+0.324	+1.807	.005	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by ACCS expression — UCEC

Explore this box plot interactively →