ACCS

Across TCGA cell cohorts, ACCS mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACCS-associated genes across cancer lineages are MTRNR2L10, GSG1L2, and CFHR1. Each is linked with ACCS in more than 1 cancer types. Because this analysis shows association rather than direction, both ACCS-to-partner and partner-to-ACCS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L10 grouped by ACCS-low versus ACCS-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACCS→partner) and Y-score (partner→ACCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MTRNR2L10 →	+0.006	+5.196	<.001	.005	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LARGE_INTESTINE	CFHR1 →	+0.095	+3.333	.006	.009	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MTRNR2L10 by ACCS expression — OVARY

Explore this box plot interactively →