ACBD6

Across TCGA patient cohorts, ACBD6 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACBD6-associated genes across cancer lineages are JNK2, MEK1, and MSH2. Each is linked with ACBD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACBD6-to-partner and partner-to-ACBD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by ACBD6-low versus ACBD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACBD6→partner) and Y-score (partner→ACBD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.220	+3.169	.043	.020	3	1
UCEC	MEK1 →	+0.470	+3.169	.019	.020	3	1
UCEC	MSH2 →	-0.275	-2.990	.030	.036	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.500	-3.000	.043	.036	3	1
UCEC	Annexin-1 →	+0.727	+3.019	.011	.019	3	1
UCEC	STAT3_pY705 →	-0.551	-2.990	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

JNK2 by ACBD6 expression — UCEC

Explore this box plot interactively →