ACBD5

Across TCGA patient cohorts, ACBD5 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACBD5-associated genes across cancer lineages are Caspase-7-cleavedD198, Caspase-8, and GAPDH. Each is linked with ACBD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACBD5-to-partner and partner-to-ACBD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ACBD5-low versus ACBD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACBD5→partner) and Y-score (partner→ACBD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.786	+2.604	<.001	.005	3	2
UCEC	Caspase-8 →	-0.211	-1.847	.036	.049	3	2
UCEC	GAPDH →	+0.449	+1.906	.037	.016	3	1
UCEC	INPP4B →	-0.366	-3.459	.004	.005	3	1
UCEC	JNK2 →	+0.223	+1.906	.005	.016	3	1
UCEC	MEK1 →	+0.557	+3.906	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Caspase-7-cleavedD198 by ACBD5 expression — UCEC

Explore this box plot interactively →