ACBD3

Across TCGA patient cohorts, ACBD3 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACBD3-associated genes across cancer lineages are 14-3-3_beta, EGFR, and eIF4E. Each is linked with ACBD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACBD3-to-partner and partner-to-ACBD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ACBD3-low versus ACBD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACBD3→partner) and Y-score (partner→ACBD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.082	-1.973	.020	.029	3	1
UCEC	EGFR →	-0.156	-2.115	.005	.017	3	1
UCEC	eIF4E →	+0.155	+2.222	.037	.010	3	1
UCEC	A-Raf_pS299 →	-0.137	-3.807	.001	<.001	3	1
UCEC	ERK2 →	+0.173	+2.115	.011	.016	3	1
UCEC	JNK_pT183_Y185 →	-0.199	-2.379	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

14-3-3_beta by ACBD3 expression — UCEC

Explore this box plot interactively →