ACAT2

Across TCGA patient cohorts, ACAT2 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,400 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ACAT2-associated proteins across cancer lineages are HMGCS1, MCM2, and MCM3. Each is linked with ACAT2 in more than 7 cancer types. Because this analysis shows association rather than direction, both ACAT2-to-partner and partner-to-ACAT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACAT2 versus HMGCS1 in HNSC, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAT2→partner) and Y-score (partner→ACAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HMGCS1 →	+0.876	+1.275	<.001	<.001	3	8
GBM	MCM2 →	+0.768	+0.624	<.001	<.001	3	7
GBM	MCM3 →	+0.703	+0.544	<.001	<.001	3	7
UCEC	MCM6 →	+0.538	+0.733	<.001	.002	3	7
LSCC	FDFT1 →	+0.732	+0.674	<.001	<.001	3	7
OV	SMC2 →	+0.583	+0.792	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,400 associations by consensus.

ACAT2 vs HMGCS1 — HNSC

Explore this scatter interactively →