ACAT2

Across TCGA patient cohorts, ACAT2 protein abundance is significantly associated with the RNA expression of many other genes, with 12,363 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ACAT2-associated genes across cancer lineages are HMGCS1, SREBF2, and HBS1L. Each is linked with ACAT2 in more than 5 cancer types. Because this analysis shows association rather than direction, both ACAT2-to-partner and partner-to-ACAT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACAT2 versus HMGCS1 in HNSC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAT2→partner) and Y-score (partner→ACAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HMGCS1 →	+0.804	+0.534	.001	<.001	3	6
OV	SREBF2 →	+1.016	+0.493	<.001	<.001	3	6
BRCA	HBS1L →	+0.476	+0.304	.001	.003	3	6
BRCA	KATNA1 →	+0.418	+0.291	.003	.006	3	6
LSCC	TBPL1 →	+0.503	+0.353	<.001	<.001	3	6
LSCC	CASP8AP2 →	+0.570	+0.420	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,363 associations by consensus.

ACAT2 vs HMGCS1 — HNSC

Explore this scatter interactively →