ACAT2

Across TCGA patient cohorts, ACAT2 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACAT2-associated genes across cancer lineages are p62 Lck ligand, ASNS, and eIF4E. Each is linked with ACAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACAT2-to-partner and partner-to-ACAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ACAT2-low versus ACAT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAT2→partner) and Y-score (partner→ACAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.667	+3.321	<.001	.010	3	1
UCEC	ASNS →	+0.612	+3.000	.001	.036	3	1
UCEC	eIF4E →	+0.251	+3.000	.023	.036	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

p62 Lck ligand by ACAT2 expression — UCEC

Explore this box plot interactively →