ACAP2

Across TCGA patient cohorts, ACAP2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACAP2-associated genes across cancer lineages are ASNS, ATM, and Caspase-7-cleavedD198. Each is linked with ACAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACAP2-to-partner and partner-to-ACAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ACAP2-low versus ACAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAP2→partner) and Y-score (partner→ACAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.483	+2.584	<.001	.010	3	2
UCEC	ATM →	-0.488	-1.502	.003	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.704	+2.341	.001	.003	3	2
UCEC	14-3-3_beta →	-0.073	-1.847	.049	.049	3	1
UCEC	EGFR_pY1068 →	-0.272	-3.584	.003	.002	3	1
UCEC	eIF4E →	+0.194	+3.598	.012	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ASNS by ACAP2 expression — UCEC

Explore this box plot interactively →