ACAP2

Across TCGA cell cohorts, ACAP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,164 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ACAP2-associated GO terms across cancer lineages are Negative regulation of macroautophagy, Peptidyl-serine phosphorylation, and Peptidyl-serine modification. Each is linked with ACAP2 in more than 15 cancer types. Because this analysis shows association rather than direction, both ACAP2-to-partner and partner-to-ACAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of macroautophagy grouped by ACAP2-low versus ACAP2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAP2→partner) and Y-score (partner→ACAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of macroautophagy →	+0.067	+0.843	.004	.001	3	16
LUNG_SCLC	Peptidyl-serine phosphorylation →	+0.078	+0.638	<.001	.002	3	16
STOMACH	Peptidyl-serine modification →	+0.098	+0.711	.001	.005	3	16
LARGE_INTESTINE	Regulation of cellular response to heat →	+0.070	+0.629	<.001	<.001	3	16
SKIN	Phosphatidylinositol metabolic process →	+0.044	+0.658	<.001	<.001	3	16
SOFT_TISSUE	Golgi organization →	+0.056	+0.807	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,164 associations by consensus.

Negative regulation of macroautophagy by ACAP2 expression — PANCREAS

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