ACAP2-IT1

Across TCGA pan-cancer cohorts, ACAP2-IT1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ACAP2-IT1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ACAP2-IT1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ACAP2-IT1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUSC show a favorable association.

HNSC, UCEC, and MESO are the cancer types where ACAP2-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.427	0.299	<.001	103	view →
UCEC	DFS	Median	All	0.533	0.745	.002	48	view →
MESO	OS	Quartile	II,III,IV	0.178	0.808	.006	45	view →
OV	OS	Tertile	All	0.800	0.899	.003	38	view →
LIHC	OS	Tertile	All	0.676	0.873	<.001	32	view →
ACC	DFS	Median	All	0.302	0.618	.002	24	view →
BLCA	DFS	Quartile	All	0.436	0.747	.005	18	view →
THCA	OS	Tertile	II,III,IV	0.919	1.000	.008	18	view →
LUSC	OS	Tertile	All	0.822	0.718	.002	17	view →
KIRC	DFS	Tertile	IV	0.185	0.468	.015	16	view →
STAD	DFS	Median	IV	0.196	0.611	.004	15	view →
CHOL	DFS	Median	All	0.726	0.227	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ACAP2-IT1–HNSC (OS)

Open the HNSC breakdown →