ACAP1

Across TCGA pan-cancer cohorts, ACAP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ACAP1 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ACAP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ACAP1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where ACAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.872	0.671	.001	18	view →
LUAD	DFS	Tertile	All	0.740	0.492	.014	16	view →
HNSC	DFS	Tertile	All	1.000	0.623	.040	6	view →
UCEC	OS	Quartile	II,III,IV	1.000	0.567	.042	4	view →
LSCC	DFS	Median	II,III,IV	0.558	0.820	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ACAP1–PDAC (DFS)

Open the PDAC breakdown →