ACAP1

Across TCGA patient cohorts, ACAP1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACAP1-associated genes across cancer lineages are ATM, FoxM1, and INPP4B. Each is linked with ACAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACAP1-to-partner and partner-to-ACAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ACAP1-low versus ACAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAP1→partner) and Y-score (partner→ACAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.540	-1.938	<.001	.001	3	3
UCEC	FoxM1 →	+0.199	+1.938	.019	.001	3	2
UCEC	INPP4B →	-0.220	-2.321	.038	.005	3	2
UCEC	STAT3_pY705 →	-0.408	-1.938	<.001	.001	3	2
UCEC	eIF4E →	+0.164	+2.472	.018	.010	3	1
UCEC	Ku80 →	+0.173	+1.665	.026	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ATM by ACAP1 expression — UCEC

Explore this box plot interactively →