ACAP1

Across TCGA cell cohorts, ACAP1 mutation is significantly associated with the RNA expression of many other genes, with 644 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACAP1-associated genes across cancer lineages are OR1P1, CX3CR1, and DAO. Each is linked with ACAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACAP1-to-partner and partner-to-ACAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1P1 grouped by ACAP1-low versus ACAP1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAP1→partner) and Y-score (partner→ACAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1P1 →	+0.016	+4.415	<.001	.007	3	2
LARGE_INTESTINE	CX3CR1 →	+0.104	+2.537	.008	.008	3	2
BREAST	DAO →	+0.145	+3.758	<.001	.007	3	2
BLOOD_Leukemia	GPR101 →	+0.108	+3.551	<.001	.009	3	2
OESOPHAGUS	VSTM2B →	+0.129	+4.392	<.001	.003	3	1
STOMACH	OR2AJ1 →	+0.005	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 644 associations by consensus.

OR1P1 by ACAP1 expression — SKIN

Explore this box plot interactively →