ACAN

Across TCGA patient cohorts, ACAN protein abundance is significantly associated with the RNA expression of many other genes, with 5,426 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible ACAN-associated genes across cancer lineages are ACTC1, COL4A1, and ADGRF5. Each is linked with ACAN in more than 5 cancer types. Because this analysis shows association rather than direction, both ACAN-to-partner and partner-to-ACAN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACAN versus ACTC1 in CCRCC, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAN→partner) and Y-score (partner→ACAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ACTC1 →	+0.879	+0.741	<.001	<.001	3	6
OV	COL4A1 →	+1.197	+0.839	.004	.003	3	5
OV	ADGRF5 →	+0.986	+1.072	.008	.003	3	5
UCEC	CD93 →	+0.670	+0.464	.002	.001	3	5
CCRCC	CCDC3 →	+0.950	+0.759	<.001	<.001	3	5
COAD	MCAM →	+0.643	+0.393	.005	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,426 associations by consensus.

ACAN vs ACTC1 — CCRCC

Explore this scatter interactively →