ACAN

Across TCGA patient cohorts, ACAN mutation is significantly associated with the RNA expression of many other genes, with 6,730 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACAN-associated genes across cancer lineages are PSMD9, GLRX5, and PRC1. Each is linked with ACAN in more than 5 cancer types. Because this analysis shows association rather than direction, both ACAN-to-partner and partner-to-ACAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMD9 grouped by ACAN-low versus ACAN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAN→partner) and Y-score (partner→ACAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMD9 →	+0.334	+1.981	<.001	<.001	3	6
LUAD	GLRX5 →	+0.252	+2.284	.008	.005	3	6
UCEC	PRC1 →	+0.633	+1.440	<.001	<.001	3	6
STAD	HMBS →	+0.412	+2.475	.007	.009	3	6
STAD	UBE2S →	+0.629	+2.622	.004	.005	3	5
UCEC	CKS2 →	+0.517	+2.115	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,730 associations by consensus.

PSMD9 by ACAN expression — UCEC

Explore this box plot interactively →