ACAN

Across TCGA patient cohorts, ACAN mutation is significantly associated with the total protein of many other genes, with 84 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACAN-associated genes across cancer lineages are Cyclin-B1, ASNS, and MIG-6. Each is linked with ACAN in more than 4 cancer types. Because this analysis shows association rather than direction, both ACAN-to-partner and partner-to-ACAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ACAN-low versus ACAN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAN→partner) and Y-score (partner→ACAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.545	+1.494	<.001	.001	3	5
COAD	ASNS →	+0.628	+2.700	<.001	.005	3	5
COAD	MIG-6 →	+0.087	+1.474	.009	.026	3	4
LUAD	PKC-delta_pS664 →	-0.098	-1.983	.025	.009	3	3
LUAD	c-Jun_pS73 →	+0.139	+2.824	.021	.034	3	3
STAD	eIF4E →	+0.175	+2.222	.011	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

Cyclin-B1 by ACAN expression — UCEC

Explore this box plot interactively →