ACAN

Across TCGA cell cohorts, ACAN mutation is significantly associated with the RNA expression of many other genes, with 517 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACAN-associated genes across cancer lineages are SMIM23, TAOK3, and TH. Each is linked with ACAN in more than 1 cancer types. Because this analysis shows association rather than direction, both ACAN-to-partner and partner-to-ACAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM23 grouped by ACAN-low versus ACAN-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAN→partner) and Y-score (partner→ACAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SMIM23 →	+0.024	+3.285	<.001	.009	3	2
SKIN	TAOK3 →	-0.665	-2.395	.001	.007	3	2
BLOOD_Leukemia	TH →	+0.061	+2.487	.002	.004	3	2
BLOOD_Leukemia	PRR23D2 →	+0.110	+2.675	.001	.001	3	2
SKIN	ASB2 →	-1.051	-2.371	<.001	<.001	3	2
SKIN	SNTA1 →	-0.664	-3.321	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 517 associations by consensus.

SMIM23 by ACAN expression — BLOOD_Myeloma

Explore this box plot interactively →