ACAN

Across TCGA cell cohorts, ACAN mutation is significantly associated with the mutation status of many other genes, with 5,518 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACAN-associated genes across cancer lineages are SVEP1, MTUS2, and ARHGAP32. Each is linked with ACAN in more than 6 cancer types. Because this analysis shows association rather than direction, both ACAN-to-partner and partner-to-ACAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SVEP1 grouped by ACAN-low versus ACAN-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAN→partner) and Y-score (partner→ACAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SVEP1 →	+2.321	+2.618	.004	.004	1	7
OESOPHAGUS	MTUS2 →	+3.087	+4.000	.008	.008	1	6
OESOPHAGUS	ARHGAP32 →	+4.672	+4.672	.001	.001	1	6
BLOOD_Leukemia	MEGF8 →	+1.847	+2.087	.004	.004	1	6
BLOOD_Lymphoma	CDH9 →	+4.754	+3.362	.002	.002	1	6
BLOOD_Leukemia	RIMS1 →	+2.847	+2.386	.007	.007	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,518 associations by consensus.

SVEP1 by ACAN expression — BLOOD_Lymphoma

Explore this box plot interactively →