ACADVL

Across TCGA cell cohorts, ACADVL mutation is significantly associated with the RNA expression of many other genes, with 133 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACADVL-associated genes across cancer lineages are GZMK, NCR1, and TP53TG3C. Each is linked with ACADVL in more than 1 cancer types. Because this analysis shows association rather than direction, both ACADVL-to-partner and partner-to-ACADVL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMK grouped by ACADVL-low versus ACADVL-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACADVL→partner) and Y-score (partner→ACADVL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GZMK →	+0.005	+4.614	<.001	.004	3	1
PANCREAS	NCR1 →	+0.029	+4.786	<.001	.001	3	1
PANCREAS	TP53TG3C →	+0.487	+4.237	<.001	.006	3	1
PANCREAS	SLC5A8 →	+0.005	+4.614	<.001	.004	3	1
PANCREAS	TP53TG3B →	+0.313	+4.011	<.001	.009	3	1
PANCREAS	CBLN4 →	+0.005	+4.614	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 133 associations by consensus.

GZMK by ACADVL expression — PANCREAS

Explore this box plot interactively →