ACADS

Across TCGA pan-cancer cohorts, ACADS mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ACADS data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ACADS mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ACADS expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where ACADS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.912	.013	48	view →
CCRCC	DFS	Quartile	All	0.978	0.343	.003	13	view →
PDAC	DFS	Quartile	All	0.610	0.215	.002	12	view →
LUAD	DFS	Quartile	II,III,IV	0.739	1.000	.009	6	view →
HNSC	DFS	Tertile	II,III,IV	0.901	0.990	.027	4	view →
GBM	OS	Tertile	All	0.303	0.545	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ACADS–COAD (DFS)

Open the COAD breakdown →