ACADS

Across TCGA patient cohorts, ACADS mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACADS-associated genes across cancer lineages are PRDX1, PREX1, and FoxM1. Each is linked with ACADS in more than 1 cancer types. Because this analysis shows association rather than direction, both ACADS-to-partner and partner-to-ACADS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by ACADS-low versus ACADS-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACADS→partner) and Y-score (partner→ACADS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PRDX1 →	+0.237	+2.832	.004	.035	2	2
COAD	PREX1 →	+0.290	+2.832	.011	.035	3	1
UCEC	FoxM1 →	+0.231	+2.115	.041	.019	3	1
UCEC	MEK1 →	+0.420	+3.321	.008	.009	3	1
UCEC	Tuberin →	+0.304	+2.115	.009	.019	3	1
UCEC	Cyclin-B1 →	+0.483	+2.999	.049	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PRDX1 by ACADS expression — COAD

Explore this box plot interactively →