ACADM

Across TCGA pan-cancer cohorts, ACADM mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ACADM data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ACADM mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ACADM expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where ACADM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.779	0.369	<.001	29	view →
PDAC	DFS	Tertile	IV	0.726	0.199	.024	13	view →
CCRCC	OS	Median	III,IV	1.000	0.353	.022	10	view →
HNSC	DFS	Median	IV	1.000	0.413	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ACADM–LUAD (DFS)

Open the LUAD breakdown →