ACADL

Across TCGA patient cohorts, ACADL mutation is significantly associated with the RNA expression of many other genes, with 2,946 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACADL-associated genes across cancer lineages are SNRPGP17, MTND5P19, and OLIG3. Each is linked with ACADL in more than 1 cancer types. Because this analysis shows association rather than direction, both ACADL-to-partner and partner-to-ACADL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPGP17 grouped by ACADL-low versus ACADL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACADL→partner) and Y-score (partner→ACADL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPGP17 →	+0.174	+1.698	.004	.001	3	2
SKCM	MTND5P19 →	+0.022	+3.449	<.001	.009	3	2
READ	OLIG3 →	+0.235	+4.421	<.001	.009	3	2
READ	MIR4774 →	+0.627	+5.257	<.001	.002	3	2
HNSC	RNU1-35P →	+0.291	+4.578	<.001	.008	3	2
HNSC	RNU1-57P →	+0.258	+5.608	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,946 associations by consensus.

SNRPGP17 by ACADL expression — UCEC

Explore this box plot interactively →